Jalen Hurts sprained his right shoulder against the Chicago Bears on Sunday.
Backup Gardner Minshew will most likely start against the Dallas Cowboys.
Hurts was a nonparticipant at practice Tuesday and Wednesday.
Coach Nick Sirianni calls Hurts "the toughest player I've ever been around".
Alabama quarterback Jalen Hurts suffered a shoulder injury in the Eagles' win over the Bears.
Hurts was named the NFC's starting quarterback for the 2023 Pro Bowl on Wednesday.
He completed 67.3% of his throws for 3,472 yards, 22 scores and five interceptions this season.
Minswg completed 2 of 4 passes for 34 yards in three appearances this season.
The Cowboys (10-4) will host the Eagles (13-1) at AT&T Stadium in Arlington, Texas, on Saturday.